EHUD KEINAN
PUBLICATIONS
BOOKS
E. Keinan and I. Schechter, Eds., Chemistry for the 21st Century, Wiley-VCH, 2001.
E. Keinan, I. Schechter, Michael Sela, Eds., Life Sciences for the 21st Century, Wiley-VCH, 2002.
E. Keinan, Ed., Catalytic Antibodies, Wiley-VCH, 2005.
PATENTS
Y. Mazur, Z. Cohen, E. Keinan, and T.H. Varkony, Production of alcohols and ketones. Israel Pat. no. 47344 (1975).
Y. Mazur, Z. Cohen, E. Keinan, Process and novel intermediates for the production of 125-dihydroxy vitamin D3. Israel Pat. no. 49287 (1976).
Y. Mazur and E. Keinan, The production of aldehydes and ketones from organic nitro compounds. Israel Pat. no. 48423 (1977).
E. Keinan and A. Nudelman, Process for the production of glucuronides. Israel Pat. no. 69642 (1983).
E. Keinan and A. Nudelman, Derivatives of podophilotoxin and their preparation. Israel Pat. no. 69643 (1983).
E. Keinan and D. Eren, Production of polyprenoid and ubiquinone-type compounds. Israel Pat. no. 71482 (1985).
E. Keinan and S. Kumar, Applications of tricycloquinazoline derivatives. Israel Pat.; US Pat. (1993).
E. Keinan and S. Kumar, Photoconductivity of tricycloquinazoline derivatives. German Pat. (1993).
E. Keinan, Metallocene anti-tumor drugs. Israel Pat.; US Pat.; German Pat.; Japan. Pat. (1993).
E. Keinan, Trispyrazolylborate anti-tumor complexes. Israel Patent application (1997).
E. Keinan and A. Shulman, Catalytic antibodies for the inactivation of herbicides. Israel Patent Application, PCT (1997).
E. Keinan and A. Shulman, Antibody-catalyzed deuteration and tritiation of carbonyl compounds. US Patent Application (1998).
E. Keinan, H. Itzhaky, and E. Pirak, Catalytic antibodies for the inactivation of mycotoxins. US Patent Application, PCT (1998).
E. Keinan, H. Itzhaky, E. Pirak, E. Almon, and S. Gepstein, Control of fruit ripening and senescence in plants. US Patent Application (1999).
E. Keinan and H. Itzhaky, Method and kit for the detection of explosives. US Patent 6,767,717 (July 27, 2004).
E. Keinan and A. Haskel, Stable dihydridoalkyl Platinum(IV) complex, methods of producing sameand utilizing same (WO 2001/05208).
M. Erez, O. Levy, and E. Keinan, Tricyclic compounds and their uses as antiarrhythmic, antifibrillatory and defibrillatory agents. US Patent 6908915 (June 21, 2005), Israeli patent 131685 (June, 9 2007).
E. Keinan, Anti-inflammatory compositions and uses thereof (WO 2004/066912).
E. Keinan, Novel synthetic binding pairs and uses thereof (WO 2005/023816), US patent application 20060292570.
E. Keinan, Calixurenes and uses thereof (Provisional #: 47109, Aug, 11, 2009).
E. Keinan Frictionless molecular rotary motors US 08715635, 2014. Patent Assignee: Technion Research and Development Foundation Ltd.
PUBLICATIONS
2016
Singh, M., Solel, E., Keinan, E., Reany, O.
Aza-bambusurils En Route to Anion Transporters. Chem. Eur. J., 2016, 22, 8848-8854. Cover art.
Solel, E., Singh, M., Reany, O., Keinan, E.
Enhanced anion binding by heteroatom replacement in bambusurils. Phys. Chem. Chem. Phys., 2016, 18, 13180-13185. Cover art.
2015
Singh, M., Solel, E., Keinan, E., Reany, O.
Dual-functional semithio-bambusurils. Chem. Eur. J., 2015, 21, 536–540.
Bibi, H., Reany, O., Waisman, D., Keinan, E.
Prophylactic treatment of asthma by an ozone scavenger in a mouse model. Bioorg. Med. Chem. Lett. 2015, 25, 342-346.
2014
Parvari, G., Annamalai, S., Borovoi, I., Chechik, H., Botoshansky, M., Pappo, D., Keinan, E.
Multifarenes: New Modular Cavitands. Chem. Comm. 2014, 50, 2494-2497.
Singh, M., Parvari, G., Botoshansky, M., Keinan, E., Reany, O.
The Synthetic Challenge of Thio-Cucurbiturils, European J. Org. Chem. 2014, 891-897. Cover Art: p. 891.
2013
Ratner, T., Piran, R., Jonoska, J. Keinan, E.
Biologically Relevant Molecular Transducer with Increased Computing Power and Iterative Abilities. Chemistry & biology 2013, 20, 726-733.
Angelova, P., Solel, E., Parvari, G., Turchanin, A., Botoshansky, M., Gölzhäuser, A., Keinan, E.
Chemisorbed Monolayers of Corannulene Penta-Thioethers on Gold. Langmuir 2013, 29, 2217–2223.
Bulatov, V., Reany, O., Grinko, R., Schechter, I., Keinan, E.
Time-Resolved, Laser Initiated Detonation of TATP Supports Previously Predicted Non-Redox Mechanism. Phys. Chem. Chem. Phys. 2013, 15, 6041-6048.
Lee, S.-H., Piran, R., Keinan, E., Pinkerton, A., Levine, F.
Induction of β‐cell replication by a synthetic HNF4α antagonist. Stem Cells 2013, 31, 2396-2407.
2012
Shoshani, S., Piran, R., Arava, Y., Ehud Keinan, E.
A Molecular Cryptosystem for Images by DNA Computing. Angew. Chem. Intl. Ed. Eng. 2012, 51, 2883-2887.
Pogoreltsev, A., Solel, E., Pappo, D., Keinan, E.
Deca-heterosubstituted corannulenes. Chem. Commun. 2012, 48, 5425–5427.
Sinha, M. K., Reany, O., Yefet, M., Botoshansky, M., Keinan.
Bistable Cucurbituril Rotaxanes Without Stoppers. Chem. Eur. J. 2012, 18, 5589-5605.
Ratner, R., Shoshani, S., Piran, R., Keinan, E.
Biomolecular Finite Automata. In Biomolecular Information Processing. Katz, E. Ed. Wiley-VCH 2012, pp. 145-179.
2011
Parvari, G., Reany, O., Keinan, E.
Applicable Properties of Cucurbiturils. Israel J. Chem. 2011, 51, 646-663.
Shoshani S., Ratner T., Piran R., Keinan, E.
Biologically Relevant Molecular Finite Automata. Israel J. Chem. 2011, 51, 67-86.
Shoshani, S., Wolf, S., Keinan, E.
Molecular computing with plant cell phenotype serving as quality controlled output. Mol. Biosys. 2011, 7, 1113-1120.
2010
Nakamaru-Ogiso, E., Han, H., Matsuno-Yagi, A., Keinan, E. Sinha, S. C., Yagi, T., Ohnishi, T.
The ND2 subunit is labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor. FEBS Lett. 2010, 584, 883-888.
Chung, C.-H., Hao, E., Piran R., Keinan, E., Levine, F.
Pancreatic beta-Cell Neogenesis by Direct Conversion from Mature alpha-Cells. Stem Cells 2010, 28, 1630-1638.
Metanis, N., Keinan, E., Dawson, P. E.
Traceless Ligation of Cysteine Peptides using Selective Deselenization. Angew. Chem. Intl. Ed. Eng. 2010, 49, 7049-7053.
Sinha, M. K., Reany, O., Parvari G., Karmakar, A., Keinan, E.
Switchable Cucurbituril-Bipyridine Beacons. Chem. Eur. J. 2010, 16, 9056-9067.
Ratner, T.; Keinan, E.
Images come to life. ChemBioChem 2010, 11, 947-949.
Shekhter, T., Metanis, N., Dawson, P. E., Keinan, E.
A residue outside the active site CXXC motif regulates the catalytic efficiency of Glutaredoxin 3. Mol. Biosys. 2010, 6, 241-248.
2009
Gershoni-Poranne, R., Pappo, D., Solel, E., Keinan E.
Corannulene Ethers via Copper Catalysis. Org. Lett. 2009, 11, 5146-5149.
Piran, R., Halperin, E., Guttmann-Raviv, E., Keinan, E., Reshef, R.
Algorithm of Myogenic Differentiation in Higher-order Organisms. Development 2009, 136, 3831-3840.
Ratner, T., Reany, O., Keinan, E.
NMR-Based Encoding and Processing of Alphanumeric Information. ChemPhysChem 2009, 10, 3303-3309.
Reany, O., Kapon, M., Botoshansky, M., Keinan, E.
Rich Polymorphism in TriAcetone TriPeroxide. Cryst. Growth & Design 2009, 9, 3661-3670.
Pappo, D., Mejuch, T., Reany, O., Solel, O., Mahender, G., Keinan, E.
Diverse Functionalization of Corannulens: Easy Access to Pentagonal Superstructures. Org. Lett. 2009, 11, 1063-1065.
2008
Ben Shir, I., Sanjita Sasmal, S., Mejuch, T., Sinha, M.K., Kapon, M., Keinan, E.
Repulsive Interaction Can Be a Key Design Element of Molecular Rotary Motors. J. Org. Chem. 2008, 73, 8772-9.
2007
A. Olson, Y. H. E. Hu, E. Keinan.
Chemical mimicry of viral capsid self-assembly. Proc. Natl. Acad. Sci. USA 2007, 104, 20731-20736.
E. Kossoy, N. Lavid, M. Soreni-Harari, Y. Shoham, E. Keinan.
A Programmable Bio-Molecular Computing Machine with Bacterial Phenotype Output. ChemBioChem 2007, 8, 1255-1260.
H. C. Lo, M. A. Iron, J. M. L. Martin, E. Keinan.
Proton Walk in the Aqueous Platinum Complex TpPtMeCO via a Sticky -Methane Ligand. Chemistry - A European Journal, 2007, 13, 2812-2823. (PDF)
H. C. Lo, H. Han, L. J. D’Souza, S. C. Sinha, E. Keinan.
Rhenium(VII) Oxide-Catalyzed Heteroacylative Ring-Opening Dimerization of Tetrahydrofuran. J. Am. Chem. Soc. 2007, 129, 1246–1253. (PDF)
2006
Y. Weiss, A. Shulman, I. Ben Shir, E. Keinan, and S. Wolf.
Herbicide-resistance conferred by expression of a catalytic antibody in Arabidopsis thaliana. Nature Biotechnology 24:713-717, 2006. (PDF)
Y. Weiss, B. Rubin, A. Shulman, I. Ben Shir, E. Keinan, S. Wolf.
Determination of plant resistance to carbamate herbicidal compounds inhibiting cell division and early growth by seed and plantlets bioassays. Nature Protocols 2006, 1, 2282–2287. (PDF)
T. Tuttle, E. Keinan, W. Thiel.
Understanding the enzymatic activity of 4-oxalocrotonate tautomerase and its mutant analogues: A computational study. J. Phys. Chem. B 110(39): 19685-19695, 2006. (PDF)
N. Metanis, E. Keinan, P.E. Dawson.
Synthetic Seleno-Glutaredoxin 3: Highly Reducing Oxidoreductases with Enhanced Catalytic Efficiency. J. Am. Chem. Soc. 2006, 128, 16684-16691. (PDF)
2005
F. Dubnikova, R. Kosloff, J. Almog, Y. Zeiri, R. Boese, H. Itzhaky, A. Alt, E. Keinan.
Decomposition of triacetone triperoxide is an entropic explosion. J. Am. Chem. Soc. 127:1146-59, 2005. (PDF)
Selected by Chemical & Engineering News for commentary as a Highlight in the Science/Technology Concentrates Section, January 24, 2005, 83(4):35. (PDF)
Selected by Science for commentary as a Highlight in the Editor’s Choice Section, January 21, 2005, 307:319-321. (PDF)
S. Saphier, Y. Hu, S.C. Sinha, K.N. Houk, E. Keinan.
The origin of selectivity in the antibody 20F10-catalyzed Yang cyclization. J. Am. Chem. Soc. 127:132-45, 2005. (PDF)
E. Keinan, A. Alt, G. Amir, L. Bentur, H. Bibi, and D. Shoseyov.
Natural ozone scavenger prevents asthma in sensitized rats. Bioorg. Med. Chem. 13:557-62, 2005. (PDF)
Selected by Chemical & Engineering News for commentary as a Highlight in the Science/Technology Concentrates Section, January 3, 2005, 83(1):25. (PDF)
M. Soreni, S. Yogev, E. Kossoy, Y. Shoham, E. Keinan.
Parallel biomolecular computation on surfaces with advanced finite automata. J. Am. Chem. Soc. 127(11):3935-3943, 2005. (PDF)
N. Metanis, E. Keinan and P.E. Dawson.
A Designed Synthetic Analogue of 4-OT is Specific for a Non-Natural Substrate. J. Am. Chem. Soc. 127(16):5862-5868, 2005. (PDF)
C. Matteo, N. Jonoska, S. Yogev, R. Piran, E. Keinan, and N.C. Seeman.
Biomolecular implementation of computing devices with unbounded memory. DNA10, LNCS, C. Ferretti, G. Mauri and C. Zandron andron, Eds., Springer-Verlag, Berlin-Heidelberg, 3384:35-49, 2005. (PDF)
A. Brik, E. Keinan.
Catalytic Antibodies in Natural Products Synthesis. Catalytic Antibodies, Ehud Keinan, Ed., Wiley-VCH, Weinheim, 2005, Chapter 5, pp 132-152. (PDF).
R. Piran, E. Keinan.
In vitro Evolution of Catalytic Antibodies and Other Proteins via Combinatorial Libraries. Catalytic Antibodies, Ehud Keinan, Ed., Wiley-VCH, Weinheim, 2005, Chapter 9, pp 243-283. (PDF).
S. Saphier, R. Piran, E. Keinan.
Photoenzymes and Photoabzymes. Catalytic Antibodies, Ehud Keinan, Ed., Wiley-VCH, Weinheim, 2005, Chapter 13, pp 351-368. (PDF).
D. Kubitz, E. Keinan.
Production of Monoclonal Catalytic Antibodies: Principles and Practice. Catalytic Antibodies, E. Keinan, Ed., Wiley-VCH, Weinheim, 2005, Chapter 18, 489-502. (PDF).
2004
N. Metanis, A. Brik, P.E. Dawson, E. Keinan.
Electrostatic Interactions Dominate the Catalytic Contribution of Arg39 in 4-Oxalocrotonate Tautomerase. J. Am. Chem. Soc. 2004, 126, 12726-12727. (PDF)
H. Han, M.K. Sinha, L.J. D’Souza, E. Keinan, S.C. Sinha.
Total synthesis of 34-hydroxyasimicin and its photoactive derivative for affinity labeling of the mitochondrial Complex I. Chem. Eur. J. 2004, 10, 2149-2158. (PDF) Cover Picture: Chem. Eur. J. 2004, 10, 2101. (PDF) The cover picture shows: (PDF).
G. Sklute, R. Oizerowich, H. Shulman, E. Keinan.
Antibody-catalyzed benzoin oxidation as a mechanistic probe for nucleophlic catalysis by an active site lysine. Chem. Eur. J. 2004, 10, 2159-2165. (PDF)
S. Sasmal, M.K. Sinha, E. Keinan.
Facile purification of rare cucurbiturils by affinity chromatography. Org. Lett. 2004, 6, 1225-1228. (PDF)
2003
S. Saphier, S.C. Sinha E. Keinan.
Antibody-catalyzed enantioselective Norrish type II cyclization. Angew. Chem. Intl. Ed. Eng. 2003, 42, 1378-1381. (PDF)
2002
A. Shulman, D. Sitry, H. Shulman, E. Keinan.
Highly efficient antibody-catalyzed deuteration of carbonyl compounds. Chem. Eur. J. 8:229-39, 2002. (PDF)
H.C. Lo, A. Haskel, M. Kapon, and E. Keinan.
TpPt(IV)Me(H)2 Forms a CH4 complex that is kinetically resistant to methane liberation. J. Am. Chem. Soc. 124:3226-8, 2002. (PDF). Additions and corrections: J. Am. Chem. Soc. 124:3226-8, 2002. (PDF)
E. Keinan, S.C. Sinha.
Oxidative polycyclizations with rhenium(VII)oxides. Pure Appl. Chem. 74:93-105, 2002. (PDF)
M.A. Iron, H.C. Lo, J.M.L. Martin, E. Keinan.
TpPtMeH2: Why is there H/D scrambling of the methyl group but not methane loss? J. Am. Chem. Soc. 2001, 124, 7041-54. (PDF)
A. Brik, L.J. D’Souza, E. Keinan, F. Grynszpan, P.E. Dawson.
Mutants of 4-Oxalocrotonate tautomerase catalyze the decarboxylation of oxaloacetate through an imine mechanism. ChemBioChem 3:845-51, 2002. (PDF)
Cover: ChemBioChem, September 2, 2002, 3(9) (PDF); The cover picture shows: (PDF)
A. Brik, P.E. Dawson, E. Keinan.
The product of the natural reaction catalyzed by 4-oxalocrotonate tautomerase becomes an affinity label of its mutant. Bioorg. Med. Chem. 10:3891-7, 2002. (PDF)
2001
Y. Benenson, T. Paz-Elizur, R. Adar, E. Keinan, Z. Livneh, E. Shapiro.
Programmable and autonomous computing machine made of biomolecules. Nature 414:430-4, 2001. (PDF)
L.J. D’Souza, S.C. Sinha, S.-F. Lu, E. Keinan, S.C. Sinha.
Oxidative polycyclization with rhenium(VII) oxides. Application of the stereoselectivity rules in the total synthesis of Rollidecins C and D. Tetrahedron 57:5255, 2001. (PDF)
O. Levy, M. Erez, D. Varon, E. Keinan.
A new class of antiarrhythmic-defibrillatory agents. Bioorg. Med. Chem. Lett. 11:2921-6, 2001. (PDF)
2000
A. Brik, E.. Keinan, P.E. Dawson.
Protein synthesis by solid-phase chemical ligation using a safety catch linker. J. Org. Chem. 65:3829-35, 2000. (PDF)
H. Shulman, A. Eberhard, C. Eberhard, S. Ulitzur, E. Keinan.
Highly sensitive and rapid detection of antibody catalysis by luminescent bacteria. Bioorg. Med. Chem. Lett. 10:2353-6, 2000. (PDF)
H. Avedissian, S.C. Sinha, A. Yazbak, A. Sinha, P. Neogi, S.C. Sinha, E. Keinan.
Total synthesis of asimicin and bullatacin. J. Org. Chem. 65:6035-51, 2000. (PDF)
H. Shulman, C. Makarov, A.K. Ogawa, F. Romesberg, E. Keinan.
Chemically reactive immunogens lead to functional convergence of the immune response. J. Am. Chem. Soc. 122:10743-53, 2000. (PDF)
H. Shulman E. Keinan.
Catalysis of the kemp elimination by natural coals. Org. Lett. 23:3747-50, 2000. (PDF)
1999
A. Sinha, S.C. Sinha, S.C. Sinha, E. Keinan.
Total synthesis of trilobin. J. Org. Chem. 64:2381-6, 1999. (PDF)
A. Shulman, E. Keinan, D. Shabat, C.F. Barbas III.
Teaching catalytic antibodies to undergraduate students: An organic chemistry lab experiment. J. Chem. Ed. 76:977-82, 1999. (PDF)
H. Shulman and E. Keinan. Substrate-selective mechanisms in biocatalysis demonstrated with a versatile and efficient aldolase antibody. Bioorg. Med. Chem. Lett. 9:1745-50, 1999. (PDF)
S.C. Sinha, S.C. Sinha, and E. Keinan. Total synthesis of squamotacin. J. Org. Chem. 64:7067-73, 1999. (PDF)
S. Nimri and E. Keinan. Antibody-metalloporphyrin catalytic assembly mimics natural oxidation enzymes. J. Am. Chem. Soc. 121:8978-82, 1999. (PDF)
F. Grynszpan and E. Keinan. Opsin shift in an aldolase antibody. Bioorg. Med. Chem. Lett. 9:2419-24, 1999. (PDF)
A. Haskel and E. Keinan. Formation of a stable dihydridoalkyl Pt(IV) complex by water activation. Organometallics 18:4677-80, 1999. (PDF)
A. Haskel and E. Keinan. TPM: a new protecting group for alkynes. Tetrahedron Letters 40:7861-5, 1999. (PDF)
1998
F. Grynszpan and E. Keinan. Use of antibodies to dissect the components of a catalytic event. The cyclopropenone hapten. Chem. Commun. (Cambridge) 8:865-6, 1998. (PDF)
S.C. Sinha, A. Sinha, S.C. Sinha, and E. Keinan. Total synthesis of goniocin and cyclogoniodenin T. Unique biosynthetic event. J. Am. Chem. Soc. 120:4017-8, 1998. (PDF)
D. Shabat H. Shulman, H. Itzhaky, J.-L. Reymond, and E. Keinan. Enantioselectivity vs. kinetic resolution in antibody catalysis: formation of the (S) product despite preferential binding of the (R) intermediate. Chem. Commun. (Cambridge) 1759-60, 1998. (PDF)
A. Yazbak, S.C. Sinha, and E. Keinan. Total synthesis of uvaricin, J. Org. Chem. 63:5863-8, 1998. (PDF)
P. Neogi, T. Doundoulakis, A. Yazbak, S.C. Sinha, S.C. Sinha, and E. Keinan. Total synthesis of mucocin. J. Am. Chem. Soc. 120:11279-84, 1998. (PDF)
S.C. Sinha, E. Keinan, S.C. Sinha. Rules of stereoselectivity in tandem oxidative polycyclization reactions with rhenium(VII) oxides. J. Am. Chem. Soc. 120:9076-7, 1998. (PDF). Correction: J. Am. Chem. Soc. 120:11542, 1998. (PDF)
1997
S.C. Sinha and E. Keinan. Total synthesis of (+)-aspicilin. The naked carbon skeleton strategy vs the bioorganic approach. J. Org. Chem. 62:377-86, 1997. (PDF) Supporting Information (PDF)
E. Keinan, A. Sinha, A. Yazbak, S.C. Sinha, and S.C. Sinha. Towards chemical libraries of annonaceous acetogenins. Pure. Appl. Chem. 69:423-30, 1997. (PDF)
D. Shabat, F. Grynszpan, S. Saphier, A. Turniansky, D. Avnir, and E. Keinan. An efficient sol-gel reactor for antibody catalyzed transformations. Chem. Mater. 9:2258-60, 1997. (PDF)
S.C. Sinha, A. Sinha, S.C. Sinha, and E. Keinan. Tandem oxidative cyclization with rhenium oxide. Total synthesis of 17,18-Bisepi- goniocin. J. Am. Chem. Soc. 119:12014-5, 1997. (PDF)
1996
P. Ghosh, D. Shabat, S. Kumar, S.C. Sinha, F. Grynszpan, J. Li, L. Noodleman, and E. Keinan. Using antibodies to perturb the coordination sphere of a transition metal complex. Nature 382:339-41, 1996. (PDF)
Selected by Chemical & Engineering News for commentary as a Highlight in the Science/Technology Concentrates Section, 29 July, 1996, p. 40. (PDF)
E. Keinan and R.A. Lerner. The first decade of antibody catalysis: Perspective and prospects. Israel J. Chem. 36:113-9, 1996. (PDF)
S.C. Sinha and E. Keinan. -Multistriatin: The first total synthesis of a natural product via antibody catalysis. Israel J. Chem. 36:185-93, 1996. (PDF)
E. Keinan, S.C. Sinha, D. Shabat, H. Itzhaky, and J.L. Reymond. Asymmetric organic synthesis with catalytic antibodies. Acta Chem. Scand. 50:679-87, 1996. (PDF)
S.C. Sinha, A. Sinha, A. Yazbak, and E. Keinan. Towards chemical libraries of annonaceous acetogenins. Total synthesis of trilobacin. J. Org. Chem. 61:7640-1, 1996. (PDF). Supporting Information (PDF)
D. Shabat, S.C. Sinha, J.-L. Reymond, and E. Keinan. Catalytic antibodies as probes of evolution. Modeling of a primordial glycosidase. Angew. Chem. Int. Ed. Eng. 35:2628-30, 1996. (PDF)
1995
S.C. Sinha, A. Sinha-Bagchi, E. Keinan.
Combined osmium-rhenium approach to synthesis of naturally occurring polyethers. J. Am. Chem. Soc. 1995, 117, 1447-1448. (PDF)
D. Shabat, H. Itzhaky, J.-L. Reymond, E. Keinan.
Antibody catalysis of a reaction otherwise strongly disfavored in water. Nature 1995, 374, 143-145. (PDF)
S.C. Sinha, E. Keinan. Catalytic antibodies in organic synthesis.
Asymmetric synthesis of a (-)-alpha multistriatin. J. Am. Chem. Soc. 1995, 117, 3653-4. (PDF)
Selected by Chemical & Engineering News for commentary as a Highlight in the Science/Technology Concentrates Section, 3 April, 1995, p.19. (PDF)
H. Itzhaky, E. Keinan.
Acyl transfer vs catalysis with avidin. J. Am. Chem. Soc. 117:8482-3, 1995. (PDF)
A. Sinha-Bagchi, S.C. Sinha, E. Keinan. A practical approach to enantiomerically pure cis-epoxides. Synthesis of (+)-disparlure. Tetrahedron Asymmetry 6:2889-92, 1995. (PDF)
S.C. Sinha, A. Sinha-Bagchi, A. Yazbak, and E. Keinan. Modular approach to Annonaceous acetogenins. Total synthesis of asimicin and bullatacin. Tetrahedron Lett. 36:9257-60, 1995. (PDF)
1994
S.C. Sinha and E. Keinan. Short synthesis of (+) aspicilin via asymmetric hexahydroxylation of a triene. J. Org. Chem. 59:949-51, 1994. (PDF)
E. Keinan, S. Kumar, V. Dangur, J. Vaya.
Evidence for a cyclic mechanism in eta-3-allyl)palladium chemistry. Promotion of beta-hydride elimination by unsaturated organometallics. J. Am. Chem. Soc. 116:11151-2, 1994. (PDF)
1993
S.C. Sinha, E. Keinan. Total synthesis of naturally occurring acetogenins: Solamin and Reticulatacin. J. Am. Chem. Soc. 115:4891-2, 1993. (PDF)
S.C. Sinha, E. Keinan, J.-L. Reymond. Antibody-catalyzed enantioselective epoxide hydrolysis. J. Am. Chem. Soc. 115:4893-4, 1993. (PDF)
S. Kumar, E.J. Wachtel, E. Keinan. Hexaalkoxytricycloquinazolines: New discotic liquid crystals. J. Org. Chem. 58:3821-7, 1993. (PDF)
M. Peretz, O. Bogin, E. Keinan, and Y. Burstein. Stereospecificity of hydrogen transfer by the NADP-linked alcohol dehydrogenase from the thermophilic bacterium Thermoanaerobium brockii. Int. J. Peptide Protein Res. 42:490-5, 1993. (PDF)
S.C. Sinha, E. Keinan, and J.-L. Reymond. Antibody-catalyzed reversal of chemoselectivity. Proc. Natl. Acad. Sci. USA 90:11910-3, 1993. (PDF)
S.C. Sinha, A. Sinha-Bagchi, and E. Keinan. A general approach to enantiomerically pure methyl carbinols. Asymmetric synthesis of antibiotic (-)-A26771B and the WCR sex pheromone. J. Org. Chem. 58:7789-96, 1993. (PDF)
1992
E. Keinan, S. Kumar, S. P. Singh, R. Ghirlando and E.J. Wachtel. New discotic liquid crystals having a tricycloquinazoline core. Liquid Crystals 11:157-73, 1992. (PDF)
E. Keinan, S.C. Sinha, and A. Sinha-Bagchi. Thermostable enzymes in organic synthesis. 7.Total synthesis of the western corn rootworm sex pheromone, 8-methyldec-2-yl propanoate using a TBADH-generated C2-bifunctional chiron. J. Org. Chem. 57:3631-6, 1992. (PDF)
Z.-M. Wang, X.-L. Zhang, K.B. Sharpless, S.C. Sinha, A. Sinha-Bagchi, and E. Keinan. A general approach to -lactones via osmium-catalyzed asymmetric dihydroxylation. synthesis of (-)- and (+)-muricatacin. Tetrahedron Lett. 33:6407-10, 1992. (PDF)
E. Keinan, S.C. Sinha, A. Sinha-Bagchi, Z.-M. Wang, X.-L. Zhang, and K.B. Sharpless. Synthesis of all four isomers of disparlure using osmium-catalyzed asymmetric dihydroxylation. Tetrahedron Lett. 33:6411-4, 1992. (PDF)
E. Keinan, E. Benory, S.C. Sinha, A. Sinha-Bagchi, D. Eren, Z. Eshhar and B.S. Green, Catalytic antibodies. Circular dichroism and UV-vis studies of antibody-metalloporphyrin interactions. Inorg. Chem. 31:5433-8, 1992. (PDF)
1991
E. Keinan and N. Greenspoon. Partial reduction of enones, styrenes and related systems, in "Comprehensive Organic Chemistry"; B.M. Trost and I. Fleming, eds., Pergamon Press, Oxford 523, 1991. (PDF)
E. Keinan, S.C. Sinha and S. P. Singh, Thermostable enzymes in organic synthesis. 5. Total synthesis of S-(+)-Z-dodec-3-en-11-olide (ferrulactone II) using a TBADH-generated bifunctional chiron. Tetrahedron 47:4631-8, 1991. (PDF)
E. Keinan, M. Sahai, and R. Shvily. Diiodosilane. 4. Direct reduction of ketals and acetals in the presence of unprotected carbonyls. A case of inverted chemoselectivity. Synthesis 641-3, 1991. (PDF)
E. Keinan, S.C. Sinha, and A. Sinha-Bagchi. Thermostable enzymes in organic synthesis. Part 6. Total synthesis of S-(-) zearalenone using a TBADH-generated bifunctional chiron. J. Chem. Soc. Perkin Trans. 3333-9, 1991. (PDF)
E. Keinan, S. Kumar, R. Moshenberg, R. Ghirlando, and E. Wachtel. Trisubstituted decacyclene derivatives: Bridging the gap between the carbonaceous mesophase and discotic liquid crystals. Advanced Materials 3:251-4, 1991. (PDF)
1990
E. Keinan and Zeev Roth. Stereochemical control in palladium-catalyzed allylic etherification. Israel J. Chem. 30:305-13, 1990. (PDF)
E. Keinan, K. K. Seth, R. Lamed, R. Ghirlando, and S.P. Singh. Thermostable enzymes in organic synthesis. 4. TBADH-catalyzed preparation of bifunctional chirons. Total synthesis of S-(+)-Z-tetradec-5-en-13-olide. Biocatalysis 3:57-71, 1990. (PDF)
E. Keinan, D. Perez, M. Sahai, and R. Shvily. Diodosilane (DIS). 2. A multipurpose reagent for hydrolysis and reductive iodination of ketals, acetals, ketones and aldehydes. J. Org. Chem. 55:2927-38, 1990. (PDF)
E. Keinan and M. Sahai. Diodosilane (DIS). 3. Direct synthesis of acyl iodides from carboxylic acids, lactones, acyl chlorides and anhydrides. J. Org. Chem. 55:3922-26, 1990. (PDF)
E. Keinan, S.C. Sinha, A. Sinha-Bagchi, E. Benory, M.C. Gozi, Z. Eshhar, and B.S. Green, Towards antibody-mediated metallo-porphyrin chemistry. Pure & Appl. Chem. 62:2013-19, 1990. (PDF)
1989
E. Keinan and N. Greenspoon. Reduction of unsaturated carbonyl compounds, in "The chemistry of functional groups: Enones"; S. Patai and Z. Rappoprt, eds., John Wiley & Sons, London 923-1022, 1989. (PDF)
E. Keinan. Silicon hydrides in organic synthesis.Pure & Appl. Chem. 61:1737-46, 1989. (PDF)
1988
E. Keinan and D. Eren. Total synthesis of polyprenoid natural products via Pd(0)-catalyzed oligomerizations. Pure & Appl. Chem. 60:89-98, 1988. (PDF)
E. Keinan and D. Eren. Total synthesis of linear polyprenoids. 3. Syntheses of ubiquinones via palladium-catalyzed oligomerization of monoterpene monomers. J. Am. Chem. Soc. 110:4356-62, 1988. (PDF)
E. Keinan and Noam Greenspoon. Selective deoxygenation of unsaturated carbohydrates with Pd(0)/Ph2SiH2/ZnCl2. Total synthesis of (+)-(S,S)-(6-methyltetrahydropyran-2-yl)-acetic acid. J. Org. Chem. 53:3723-31, 1988. (PDF)
1987
A. Nudelman, J. Herzig, J. Sterling, H.E. Gottlieb, and E. Keinan. Selective deacetylation of anomeric sugar acetates with tin alkoxides. Carbohydr. Res. 162:145-52, 1987. (PDF)
E. Keinan and D. Perez. Silicon hydrides and molybdenum(0) catalyst: A novel approach for conjugate reduction of unsaturated carbonyl compounds. J. Org. Chem. 52:2576-80, 1987. (PDF)
E. Keinan and D. Eren. Total synthesis of linear polyprenoids. 2. Improved preparation of the aromatic nucleus of ubiquinone. J. Org. Chem. 52:3872-5, 1987. (PDF)
E. Keinan and Daniel Perez.
Diodosilane (DIS). 1. A novel reagent for deoxygenation of alcohols and ethers. J. Org. Chem. 52:4846-51, 1987. (PDF)
E. Keinan, Daniel Perez, and Noam Greenspoon.
Molybdenum(0)-catalyzed reductive dehalogenation of -halo ketones with phenylsilane. J. Org. Chem. 52:5570-4, 1987. (PDF)
1986
E. Keinan, E.K. Hafeli, K.K. Seth, and R. Lamed.
Thermostable enzymes in organic synthesis. 2. Asymmetric reduction of ketones with alcohol dehydrogenase from Thermoanaerobium brockii. J. Am. Chem. Soc. 1986, 108, 162-169. (PDF)
E. Keinan, K.K. Seth, and R. Lamed.
Organic synthesis with enzymes. 3. TBADH-catalyzed reduction of chloro ketones. Total synthesis of (+)-(S,S)-(6-methyltetrahydro-pyran-2-yl)-acetic acid: a civet constituent. J. Am. Chem. Soc. 1986, 108, 3474-3480. (PDF)
E. Keinan and D. Eren.
An improved method for SN2-type demethoxycarbonylation of activated esters with 4-aminothiophenol and cesium catalyst. J. Org. Chem. 51:3165-9, 1986. (PDF)
K.N. Singh, V.B. Pandey, S. Banerjee, F. Bohlmann, and E. Keinan.
Novel acyl flavone glycosides from Echinops echinatus. Chemistry & Industry (London, UK) 713-4, 1986. (PDF)
E. Keinan and E. Bosch.
Palladium catalyzed propargylic vs. allylic alkylation. J. Org. Chem. 51:4006-16, 1986. (PDF)
E. Keinan K.K. Seth, M. Sahai, and E. Berman.
Proton NMR studies of self association in the Civet constituent (+)-(S,S)-(6-methyltetrahydropyran-2-yl)-acetic acid. J. Org. Chem. 1986, 51, 4288-4291. (PDF)
E. Keinan and N. Greenspoon.
Highly chemoselective palladium-catalyzed conjugate reduction of unsaturated carbonyl compounds with silicon hydrides and zinc chloride cocatalyst. J. Am. Chem. Soc. 1986, 108, 7314-7325. (PDF)
1985
E. Keinan and N. Greenspoon.
Zinc chloride mediated conjugate reduction with silicon hydrides and palladium(0) catalyst. Tetrahedron Lett. 1985, 26, 1353-1356. (PDF)
E. Keinan, M. Sahai, Z. Roth, A. Nudelman, J. Herzig.
Organotin nucleophiles VI. Palladium catalyzed allylic etherification with tin alkoxides. J. Org. Chem. 1985, 50, 3558-3566. (PDF)
1984
S.A. Godleski, K.B. Gundlach, H.Y. Ho, E. Keinan, F. Frolow.
pi-Allyl palladium complexes of norcamphene. Structure and reactivity. Organometallics 1984, 3, 21-28. (PDF)
E. Keinan, and M. Sahai.
Regioselectivity in organo-transition-metal chemistry. A remarkable steric effect in pi-allyl palladium chemistry. J. Chem. Soc. Chem. Commun. 1984, 648-650. (PDF)
E. Keinan and N. Greenspoon.
Highly chemoselective allylic reductions with silicon hydrides and palladium catalyst. Israel J. Chem. 24:82-7, 1984. (PDF)
B. Fischer, A. Nudelman, M. Ruse, J. Herzig, and E. Keinan.
A novel method for stereoselective glucuronidation. J. Org. Chem. 1984, 49, 4988-4993. (PDF)
1983
E. Keinan and Z. Roth.
Regioselectivity in organo-transition-metal chemistry. A new indicator substrate for classification of nucleophiles. J. Org. Chem. 1983, 48, 1769-1772. (PDF)
E. Keinan, M. Sahai, and I. Kirson.
Reductive elimination of vicinal oxygen functions with palladium(0). Applications in the withanolides series. J. Org. Chem. 1983, 48, 2550-2555. (PDF)
E. Keinan and H.T. Varkony.
Ozonation of single bonds, in The chemistry of functional groups, peroxides, S. Patai, ed., John Wiley & Sons, London 649, 1983. (PDF)
E. Keinan and N. Greenspoon.
Highly chemoselective reductions with PMHS and Palladium(0) catalyst. J. Org. Chem. 1983, 48, 3545-3548. (PDF)
E. Keinan and M. Peretz.
Organotin nucleophiles. V. Palladium catalyzed allylic propargylation with allenylstannane. J. Org. Chem. 1983, 48, 5302-5309. (PDF)
1982
A. Nudelman and E. Keinan.
Ene-dicarbonyl synthons: An efficient synthesis of 3-cyanopropenal and 2-cyanovinyl ketones (4-oxo-2-alkenenitriles). Synthesis 1982, 687-689. (PDF)
E. Keinan and N. Greenspoon.
Organotin nucleophiles III, Palladium catalyzed reductive cleavage of allylic heterosubstituents with tin hydride. Tetrahedron Lett. 1982, 23, 241-244. (PDF)
E. Keinan and P.A. Gleize.
Organotin nucleophiles IV. Palladium catalyzed conjugated reduction with tin hydride. Tetrahedron Lett. 1982, 23, 477-480. (PDF)
1981
R. Lamed, E. Keinan, and J.G. Zeikus.
Potential applications of an alcohol-aldehyde/ketone oxidoreductase from thermophilic bacteria. Enz. Microb. Technol. 1981, 3, 144-148. (PDF)
D. Tal, E. Keinan, and Y. Mazur.
Reactions in dry media: Reactions of cholesterol and cholestanes on silica bound ferric chloride. Cholestane-diacholestene rearrangement. Tetrahedron 1981, 37, 4327-4330. (PDF)
1980
Z. Cohen, T.H. Varkony, E. Keinan, and Y. Mazur.
Tertiary alcohols from hydrocarbons by ozonation on silica gel: 1-adamantanol. Org. Syn. 1980, 59, 176-182. (PDF)
B.M. Trost and E. Keinan.
Enolstannanes as electrofugal groups in allylic alkylation. Tetrahedron Lett. 1980, 21, 2591-2594. (PDF)
B.M. Trost and E. Keinan.
Allystannanes as electrofugal partners in allylic alkylation. Tetrahedron Lett. 1980, 21, 2595-2598. (PDF)
B.M. Trost and E. Keinan.
Pyrrole annulation onto aldehydes and ketones via palladium catalyzed reactions. J. Org. Chem. 1980, 45, 2741-2746. (PDF)
1979
L.H. Zalkow, B.A. Ekpo, L.T. Gelbaum, R.N. Harris, III, E. Keinan, J.R. Novak, Jr., C.T. Ramming, and D. Van Derveer.
The benzofurans of Isocoma wrightii. Structure and stereochemistry. J. Nat. Prod. 1979, 42, 203-219. (PDF)
Y. Mazur, D. Tal, and E. Keinan.
Reactions in dry media. Cleavage of carbon-carbon single bonds by ozonation. J. Am. Chem. Soc. 1979, 101, 502-503. (PDF)
B.M. Trost and E. Keinan.
An approach to primary allylic amines via transition metal catalyzed reactions. Total synthesis of (+/-)-gabaculine. J. Org. Chem. 1979, 44, 3451-3457. (PDF)
1978
E. Keinan and Y. Mazur.
Reactions in dry media. Ferric chloride adsorbed on silica gel. A multipurpose, easily controllable reagent. J. Org. Chem. 1978, 43, 1020-1022. (PDF)
L.H. Zalkow, L. Gelbaum, and E. Keinan.
Isolation of the pyrrolizidine alkaloid Europine N-oxide from heliotropium maris-mortari and H. Rotundifolium. Phytochemistry 1978, 17, 172. (PDF)
B.M. Trost and E. Keinan.
Steric steering with supported palladium catalysts. J. Am. Chem. Soc. 1978, 100, 7779-7781. (PDF)
1977
E. Keinan and Y. Mazur.
Dry ozonation of amines. Conversion of primary amines to nitro compounds. J. Org. Chem. 1977, 42, 844-847. (PDF)
E. Keinan and Y. Mazur.
Reactions in dry media: A simple conversion of nitro groups into carbonyls. J. Am. Chem. Soc. 1977, 99, 3861-3862. (PDF)
1976
E. Keinan and Y. Mazur.
Hydroxylation of alkenes with ozone on silica gel. Synthesis 1976, 8, 523-524. (PDF)
Z. Cohen, E. Keinan, Y. Mazur, and A. Ulman. Hydroxylation with ozone on silica gel.
The synthesis of 1alpha,25-dihydroxy-vitamin D3. J. Org. Chem. 1976, 41, 2651-2652. (PDF)
1975
Z. Cohen, E. Keinan, Y. Mazur, and T.H. Varkony.
Dry ozonation. A method for stereoselective hydroxylation of saturated compounds on silica gel. J. Org. Chem. 1975, 40, 2141-2142. (PDF)
1972
L. H. Zalkow, E. Keinan, S. Steindel, A.R. Kalyanaraman, and J.A. Bertrand.
Absolute configuration of toxol at C-3. Vicinal H-H coupling constant in 2-alkyl-3-hydroxydihydrobenzofuranes. Tetrahedron Lett. 1972, 13, 2873-2876. (PDF)